REPORT2026-05-27·GEN (on Biohub / EvolutionaryScale)

Biohub Releases a World Model of Protein Biology

Fay Lin
COMPILED NOTES

ESMC on 2.8B sequences; ESM Atlas 6.8B seqs/1.1B structures; designed binders 36-88% hit (mini), 15-29% (antibody), nanomolar

Biohub Protein-Biology World Model

Core News

On 2026-05-27 Biohub released a protein-biology "world model" that maps proteins across the tree of life, predicts structures, and designs functional binders — built by the former EvolutionaryScale team (recruited ~7 months prior).

Key Facts

  • ESMC trained on ~2.8B sequences spanning life; covers 20,000+ human protein types.
  • ESM Atlas: maps 6.8B sequences and 1.1B predicted structures (generated in "a couple of weeks").
  • Designed binders vs EGFR, PDGFRβ, PD-L1, CTLA-4, CD45; hit rates 36–88% (compact mini-binders), 15–29% (antibody-derived); nanomolar affinity, lab-validated.

Entities

Alex Rives (Head of Science, ex-EvolutionaryScale chief scientist); Priscilla Chan & Mark Zuckerberg (Biohub cofounders). Partners: AWS Bio Discovery, Benchling, Phylo, Tamarind Bio, Modal, SandboxAQ.

Source: Biohub releases a world model of protein biology — Fay Lin, GEN, 2026-05-27. Full-text fetched.

RELATED · IN THE BASE
PAPER
UniGenX: Unified Generative Foundation Model Coupling Sequence, Structure and Function
Gongbo Zhang et al. (34 authors)
PAPER
A Survey of Downstream Applications of Evolutionary Scale Modeling (ESM) Protein Language Models
Qingyu Yang; Jiale Yu; Jie Zheng
REPORT
Isomorphic Labs — IsoDDE Engine and First Human Trials
(reporting on Isomorphic Labs)
Biohub Releases a World Model of Protein Biology | Knowledge Base | MenFem