The Index
400 dossiers · 1 need attention
A research screener for every company we cover. Search a name or ticker, then sort and triage dossiers by coverage freshness, our conviction and trading relevance.
| The best obesity asset not yet owned by Big Pharma — but the market has already priced in a near-perfect Phase 3, leaving a binary 2027 readout where the upside is a takeout and the downside is a trap-door; SC maintenance data in Q3 2026 is the next real tell. | — | 8 | |
| Best-in-class *oral* GLP-1 efficacy in the wrong race — Structure has a genuine #2 asset and a fortress balance sheet, but Lilly's orforglipron is already approved (Foundayo, Apr 2026) and Structure's Phase 3 only *starts* Q3 2026, so the bet is whether a 2.9B-cap, ~2030-launch latecomer can carve share against the most powerful franchise in pharma. WATCHING, not yet a position. | — | 8 | |
| Lead asset is dead (navacaprant 0-for-3 in Phase 3 MDD, program killed Jun 15 2026); NMRA is now a ~$280M-cap shell with ~$130M cash, two early CNS shots (NMRA-511 AD-agitation Ph2, NMRA-898 schizophrenia Ph1) and runway into Q3 2027 — a busted-binary option, not an operating thesis. WATCHING, not investable, until an NMRA-511 Phase 2b signal or a credible cash-floor/M&A backstop appears. | — | 8 | |
| A genetics-platform biotech whose lead asset just printed real proof-of-concept in a disease with zero approved drugs — and the stock fell 35% because Vertex's inaxaplin is two years ahead. The bet is whether oral once-daily APOL1 inhibition is a two-horse race or a winner-take-most one. | — | 8 | |
E Equillium, Inc.catalyst in 44d | A two-asset preclinical option on EQ504 (gut-restricted AhR modulator for UC) wrapped in a >3yr cash runway and tier-1 (RA Capital / Decheng) sponsorship — but at ~$130–185M EV the market is paying real money for a drug no human has yet taken; the entire thesis lives or dies on the mid-2026 Phase 1 PoM readout ~early 2027. | — | |
| First-ever blood-brain-barrier biologic just got approved (AVLAYAH, Mar 2026) — Denali is now a de-risked platform with a small rare-disease revenue base, but the May LUMA Parkinson's failure gutted the biggest pipeline call option, so you're paying $3.3B for a ~$525M-peak orphan drug plus optionality the market just learned to distrust. | — | 8 | |
| A burned-then-reborn aging-biology platform whose entire ~$730M cap now rests on one Phase 1 asset (oral brain-penetrant NLRP3 inhibitor BGE-102) printing best-in-class hsCRP — fully funded to 2029, but the value-creating Phase 2 readouts are still 6-18 months out and a Lilly-backed competitor (ex-Ventyx) is the same molecule class with deeper pockets. | — | 8 | |
| A levered dividend-compounder running a patent-cliff relay race — the legacy book (>40% of revenue under biosimilar/IRA attack) is being out-sprinted by Repatha/rare-disease/oncology launches, but the equity is priced for MariTide to win the obesity prize it most likely places, not wins, in. | — | 8 | |
A Altimmunecatalyst in 42d | A single-asset MASH/AUD/ALD bet on a glucagon/GLP-1 dual agonist that wins on liver biology and lean-mass-sparing but loses on raw weight loss — fully funded into 2028 with a binary AUD readout in Q3 2026 as the next free option; a derisked, heavily-shorted optionality vehicle, not a fundamentals compounder. | — |