AI-Bio (TechBio / AI Drug Discovery / Synthetic Biology)
AI-driven drug discovery, generative biology, protein foundation models, synthetic biology, autonomous labs, and the techbio thesis
PAPER
2025-08-26
UniGenX: Unified Generative Foundation Model Coupling Sequence, Structure and Function
Co-generates sequence+coordinates under functional objectives across proteins/molecules/materials; 23x protein induced-fit improvement (RMSD<2Å)
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PAPER
2025-09-21
A Survey of Downstream Applications of Evolutionary Scale Modeling (ESM) Protein Language Models
Survey of ~100 ESM papers; ESM-1b→ESM3, 8M-98B params; limitations: data bias, O(n²) compute, black-box interpretability
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REPORT
2026-05-27
Biohub Releases a World Model of Protein Biology
ESMC on 2.8B sequences; ESM Atlas 6.8B seqs/1.1B structures; designed binders 36-88% hit (mini), 15-29% (antibody), nanomolar
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REPORT
2026-04-25
Isomorphic Labs — IsoDDE Engine and First Human Trials
IsoDDE 50% vs AlphaFold-3 23.3% on hard protein-ligand cases; 17 programs; Phase 1 by end-2026; $2.1B Series B
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