Baylor Huffington Center on Aging

Type: Research lab / center Affiliation: Baylor College of Medicine, Houston, TX Department: Department of Molecular and Human Genetics Lead (on this work): Hongjie Li (corresponding author) Team: Jason B. Chen, Miranda C. Wang, Shangyu Gong

The Huffington Center is the authoring institution of the "Toward Precision Longevity" review (Frontiers in Aging, Dec 2025), which reframes the longevity field around single-cell atlases. Their central argument — aging is cell-type-specific and whole-organism interventions have inherent ceilings — is the conceptual bridge between systemic drugs (rapamycin, metformin) and targeted cellular therapies (partial reprogramming, senolytics).

Key Contributions

• Precision longevity framework — integrating single-cell atlases with targeted delivery for cell-type-specific anti-aging. (Precision Longevity)
• Identified the human atlas gap — key bottleneck for translating model-organism findings. (Precision Longevity)
• Surveyed cross-species conservation — mTOR, insulin/IGF, FOXO pathways conserved invertebrate-to-human. (Precision Longevity)

Mentioned In

• Precision Longevity — this lab authored the anchor review