The Index
400 dossiers
A research screener for every company we cover. Search a name or ticker, then sort and triage dossiers by coverage freshness, our conviction and trading relevance.
| A de-risked, cash-rich option on one binary — ABCL635 Phase 2 hot-flash data in Q3 2026 — wrapped around a platform whose old royalty engine has gone to zero; the antibody-vs-pill differentiation is plausible but unproven, and at ~$1.5B the market is already paying for a win. | — | 1 | |
A Abscicatalyst in 42d | A re-rated single-asset AI-antibody story — ABS-101's half-life miss quietly killed the old lead, so the entire ~$1.15B cap now rides on one binary (ABS-201 alopecia interim PoC, H2 2026) against a 26%-of-float short and an 18-month runway. Own the readout, not the platform. | — | 0 |
| A 20-year, ~$1.7B-deficit cautionary tale of synbio that hit the same wall every fermentation pure-play hits (scale-up economics never closed the gap to chemistry), capped by an SEC revenue-recognition charge and a Chapter 11 that wiped equity to zero — the emerged "Amyris 2.0" is a smaller, Doerr-controlled private with no public equity to buy and no edge proven; AVOID / un-investable, watch only as the canonical synbio-failure comp. | — | 8 | |
| The credible enzymatic-DNA-synthesis survivor — a real fidelity moat (1,005-base record, 50 kb clonal, ~99.9% stepwise yield) now distributed through Danaher/IDT — but it is a sub-$25M-revenue tools shop selling a faster picks-and-shovels commodity into a brutal synbio funding winter; WATCHING as a private until an IPO path or an IDT buyout crystallizes the value. | — | 8 | |
| The only AI-bio company building a proprietary, legally-clean training dataset 100x deeper than UniProt — own the data layer of TechBio and it is a generational compounder; if foundation labs (ESM, AlphaFold) reach "good enough" on public data first, it is a beautifully-sourced commodity. Watch for an EDEN-derived therapeutic deal with real economics and a priced Series C. | — | 8 | |
| "The platform pioneered AI drug discovery and was real; the public-market vehicle and the unit economics were not — a £1.5bn SPAC that destroyed ~96% of value and was taken private by its founders at a ~€40-57m carcass. UNINVESTABLE as a public name (delisted); WATCH only as a private/strategic-acquisition tell for the ai-bio thesis. The lesson, not the ticker, is the asset." | — | 8 | |
| A debt-free clinical biotech trading below net cash after the FDA rejected its lead's trial design — the platform and a 4-year runway are free, but only if the EphA2/radioconjugate pivot proves the machine can make a second winner. | — | 1 | |
| A real lab-in-the-loop antibody-engineering shop with blue-chip pharma validation (AbbVie/Lilly/Merck/Amgen) and now its own clinic-bound ADC — but it is dramatically out-capitalized ($145M vs. $1B+ peers) and is becoming a Lilly satellite; WATCHING as a private, with the IND-into-clinic 2026 prints as the only catalyst that re-rates it. | — | 8 | |
| A real, regulator-embedded biosimulation moat trading like a broken SaaS roll-up — but the bet only works if the new CEO can re-accelerate software past the +7% Q1 stall before the M&A floor (SLP at 2.5x) is the only thing holding the stock. | — | 1 | |
| The single most exciting private name in AI-bio — Chai-2/3 is the first AI antibody platform with a wet-lab-validated, repeatedly-improving hit rate AND signed pharma revenue (Lilly + Pfizer); the bet is whether a portable, lab-light software platform can defend value capture against Isomorphic's deeper engine and the platform-vs-asset value trap. WATCHING for an IPO that is 2-3 years away. | — | 8 | |
C Codexiscatalyst in 43d | A real platform with a lottery ticket attached — the legacy biocatalysis P&L is shrinking and the entire equity is a bet that enzymatic siRNA manufacturing (ECO Synthesis) becomes the standard before the cash runs out in 2027; the 4x off the $0.96 March low has front-run any GMP revenue. | — | |
| A de-risked computational-discovery option on AstraZeneca's rilvegostomig — the last surviving TIGIT bet — wrapped around a $135M cash shell and a binary 2027 ovarian readout; you are buying the royalty stream and the platform, not COM701. | — | 1 | |
| The cleanest pure-SaaS bet in AI protein engineering — Google-pedigreed, wet-lab-backed, already billing 6 of the top-25 pharma — but it has deliberately disarmed itself of the one thing that creates equity value in this field (it owns no molecule, takes no royalty, signs no IP), so it is selling a fast-commoditizing copilot whose best customers (Novo Nordisk) are simultaneously funding the open-source models that erode its moat. | — | 8 | |
| A de-risked cash shell ($373M, no debt, ~$207M EV) wrapped around a still-shrinking lab-automation pivot — the balance sheet is the asset, the income statement is the warning; long the optionality only below cash, not the story. | — | 8 | |
| A real carbon-recycling technology trapped inside a going-concern microcap — the science works, the business model to monetize it does not yet, and the equity is a binary on insiders (Khosla/Brookfield) funding a cohort-licensing pivot to cash-flow breakeven before dilution and Nasdaq erode it to zero. WATCHING with a bearish tilt. | — | 1 | |
| The most-instrumented AI drug-discovery platform with the thinnest clinical proof per dollar burned — one real Phase-2 win (REC-4881/FAP) against a $2.2B accumulated deficit, smart-money exiting (NVIDIA, Mubadala out), and a $1.67B market cap that is now a binary bet on Najat Khan converting platform optionality into a registrational asset before the cash runway forces another raise. | — | 1 | |
| A genuinely differentiated allosteric PI3Kα asset with a clean ~$642M balance sheet and runway to 2029 — but the entire equity is one Phase 3 readout (ReDiscover-2) into a class that just got a $3B Novartis validation and a first-line Roche incumbent; own the science, respect that the market is pricing a win. | — | 1 | |
| A genuinely moated physics-based drug-design platform stapled to a cash-burning pipeline it can no longer afford to develop — the software is finally being valued like software (2.5x EV/sales), and the hosted transition is depressing the very revenue line the market punishes hardest. Buy the platform, not the headline P&L; the re-rate needs ACV reacceleration + one partnered pipeline win, not a clinical miracle. | — | 1 | |
| A profitable biosimulation pure-play that the public market broke (Pro-ficiency wrote off ~$72M of a $100M deal, growth fell to single digits) — and is now exiting via a $18.50/sh all-cash Altaris take-private. The fundamental thesis is moot; the only live question is deal-closes-vs-breaks, and this closes (board-unanimous, 16% founder block locked, Q4-2026 close). Merger-arb, not a growth bet. | — | 1 | |
| Not a tools company anymore — a sub-NAV cash shell mid-conversion into Treeline's oncology pipeline; the only edge is the deal-spread between ~$325M market cap and the ~$460M net cash being delivered, and that spread is a bet on Bilenker's KRAS/BCL6 readouts, not on CyTOF. | — | 0 | |
| A real, fast-growing oncology-data + diagnostics franchise wrapped in an "AI" narrative it can't yet monetize — own the genomics flywheel, but the round-trip-flavored deals, 30-vote founder, and a CEO famous for cashing out cap the multiple until cash flow turns. | — | 1 | |
| A fortress-margin vertical-SaaS monopoly trading at a growth-stock funeral price (~20x forward EPS, near 52-wk lows) because the market is pricing a Salesforce-Agentforce CRM war that threatens the contested ~40% (Commercial) while ignoring the defensible, faster-growing ~60% (R&D/Quality); BULLISH at $153 on a 1–3Y view, but the CRM-migration-to-2030 is a real, watchable execution overhang — not a phantom. | — | 1 |